Bone-building medicine (parathyroid hormone-related protein analogue)

Abaloparatide (أبالوباراتيد)

Abaloparatide is an injection under the skin that helps the body build new bone in people with osteoporosis who are at high risk of fractures. A specialist prescribes it for a limited treatment period, usually followed by another osteoporosis medicine to keep the benefit.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Treating postmenopausal osteoporosis in women at high risk of fractures
  • Treating osteoporosis in men at high risk of fractures, where approved
  • Reducing the risk of spinal and other fractures

How it is used

  • Use it only as prescribed by your doctor, and learn how to inject from your doctor or nurse first
  • It is injected under the skin of the lower abdomen with the pen, changing the spot each time and following the leaflet to prepare the pen
  • Give the first injections sitting down, or where you can sit or lie down at once if you feel dizzy
  • Never share your pen with anyone, and take calcium and vitamin D if your doctor advises them

Possible side effects

  • Dizziness, palpitations or a fast heartbeat soon after the injection
  • Nausea, headache or tiredness
  • Redness, swelling or pain where you inject
  • Raised calcium in the blood or urine

Who should not use it

  • Allergy to abaloparatide or any ingredient of the injection
  • Children and young people whose bones are still growing
  • Paget's disease of bone, an unexplained raised alkaline phosphatase, previous radiotherapy to the bones, or cancer in the bones
  • A high blood calcium level

Before and while using it

  • It can cause a drop in blood pressure on standing and dizziness after the injection; sit or lie down until it passes and do not drive if dizzy
  • A type of bone cancer was seen in studies in rats; tell your doctor about any lasting bone pain or a new lump
  • Tell your doctor about ongoing nausea, constipation, tiredness or muscle weakness, which can mean high calcium
  • Tell your doctor if you have had kidney stones
  • The total length of treatment is limited and is set by your specialist

Medicine interactions

  • Raised calcium can increase the effect of digoxin; tell your doctor if you take it
  • Blood pressure medicines can add to dizziness after the injection
  • Do not take more calcium or vitamin D supplements than your doctor advises

Pregnancy and breastfeeding

  • It is not used in pregnancy or breastfeeding; it is meant for osteoporosis after the menopause and in men

How to store it

  • Keep new pens in the fridge and do not freeze them; after first use follow the leaflet on where to store it and for how long

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.