Biological immunosuppressant (TNF-alpha blocker)

Adalimumab (أداليموماب)

Adalimumab is a biological medicine injected under the skin. It blocks a substance in the immune system that causes inflammation. It is used for long-term inflammatory diseases of the joints, skin, bowel and eye when other treatments are not enough.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Rheumatoid arthritis, psoriatic arthritis and arthritis in children
  • Ankylosing spondylitis
  • Moderate to severe psoriasis and hidradenitis suppurativa
  • Crohn's disease and ulcerative colitis
  • Non-infectious uveitis (eye inflammation)

How it is used

  • It is injected under the skin only as your specialist prescribed; they decide the dose and schedule
  • After training, you or a family member can inject into the tummy or thigh, using a different place each time
  • Take the pen out of the fridge for the time stated in the leaflet before injecting so it reaches room temperature; do not shake it
  • Always carry your patient alert card

Possible side effects

  • Redness, pain or swelling where you inject
  • Infections such as colds, sinus, chest or urine infections
  • Headache, rash or nausea
  • Rare but serious: severe infections, tuberculosis, or cancers such as lymphoma

Who should not use it

  • Active tuberculosis or another severe infection
  • Moderate to severe heart failure
  • Allergy to adalimumab

Before and while using it

  • Your doctor will test for tuberculosis and hepatitis B before you start
  • Tell your doctor straight away about fever, a lasting cough, weight loss or any sign of infection
  • Do not have live vaccines during treatment; ask your doctor which vaccines you should have
  • Tell your doctor if you have heart disease, a nerve disease such as multiple sclerosis, or have had cancer
  • Check your skin regularly and tell your doctor about any changes

Medicine interactions

  • Live vaccines
  • It is not combined with other biological medicines such as anakinra or abatacept
  • It is often used with methotrexate if the doctor decides

Pregnancy and breastfeeding

  • Tell your doctor if you are pregnant or planning a pregnancy; treatment may continue if the doctor decides, and your baby's live vaccines may need to be delayed if exposed in the womb
  • Only very small amounts pass into breast milk; ask your doctor

How to store it

  • Keep it in the fridge, do not freeze it, and keep it in the outer carton to protect it from light
  • It can be kept out of the fridge for a limited time as the leaflet says, out of the sight and reach of children

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.