Antiarrhythmic and diagnostic vasodilator

Adenosine (أدينوسين)

Adenosine is a very short-acting intravenous medicine used in hospital to stop selected fast heart rhythms or during certain cardiac tests. It can briefly cause profound slowing of the heart or breathing problems, so monitoring and resuscitation facilities are essential.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Restoring normal rhythm in selected supraventricular tachycardias
  • Helping diagnose selected regular broad-complex tachycardias
  • Producing temporary coronary vasodilation during cardiac perfusion testing

How it is used

  • It is given only by a healthcare professional through a vein where cardiac monitoring and resuscitation are available
  • Rapid injection and cardiac testing use different administration methods selected by the team
  • Tell the team about asthma, heart disease, seizures, all medicines and stimulants
  • Follow instructions about avoiding caffeine and medicines before a cardiac test

Possible side effects

  • Flushing or headache
  • Chest pressure, pain or palpitations
  • Breathlessness or an urge to breathe deeply
  • Dizziness, nausea or a feeling of apprehension
  • Rarely, profound bradycardia, cardiac arrest, a dangerous arrhythmia or seizure

Who should not use it

  • Selected heart-conduction disorders or sick-sinus syndrome without a suitable pacemaker
  • Active asthma or severe bronchospasm
  • Allergy to adenosine or any ingredient
  • Uncorrected severe low blood pressure

Before and while using it

  • It can cause transient cardiac arrest or a dangerous rhythm, so resuscitation must be immediately available
  • It can cause severe bronchospasm, particularly in people with asthma
  • Tell the team immediately about severe chest pain, sudden weakness, breathing difficulty or neurological symptoms
  • Seizures can occur and any epilepsy history must be disclosed
  • Perfusion-test risks differ from rapid injection for tachycardia, and the team must select the correct product

Medicine interactions

  • Caffeine and theophylline can reduce its effect
  • Dipyridamole can greatly increase its effect
  • Carbamazepine can increase slowing of heart conduction
  • Medicines affecting heart rhythm or blood pressure need review before use

Pregnancy and breastfeeding

  • Tell the team if you are pregnant or breastfeeding; it is used when the benefit of the procedure or treatment outweighs expected risks

How to store it

  • It is stored and prepared by the hospital according to the product instructions and not used if the solution is not clear

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.