Vascular endothelial growth factor inhibitor

Aflibercept (أفليبرسبت)

Aflibercept is injected into the eye to reduce abnormal blood-vessel growth and leakage. Specialists use it for retinal and macular diseases, and it can cause infection, retinal detachment or raised eye pressure.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Treating wet age-related macular degeneration
  • Treating macular oedema caused by diabetes or retinal-vein occlusion
  • Treating myopic choroidal neovascularisation
  • Treating selected stages of retinopathy of prematurity

How it is used

  • A qualified eye doctor injects it into the vitreous using sterile technique
  • The eye is numbed and disinfected before injection and its pressure is monitored afterwards
  • Attend examinations and injections scheduled according to the eye's response
  • Do not rub the eye and follow aftercare and eye-drop instructions

Possible side effects

  • Eye pain, redness or a small surface bleed
  • Floaters, blurred vision or raised eye pressure
  • Vitreous detachment or lens opacity
  • Rarely, infection inside the eye or retinal tear and detachment

Who should not use it

  • Allergy to aflibercept or any ingredient
  • Infection in or around the eye
  • Active severe inflammation inside the eye

Before and while using it

  • Seek urgent assessment for increasing pain, redness, light sensitivity, discharge or worsening vision
  • Flashes, increased floaters or a curtain-like shadow can indicate a retinal tear
  • Tell the doctor about glaucoma, eye surgery, or a recent heart attack or stroke
  • There is a theoretical arterial-clot risk with vascular-growth-factor inhibitors
  • A vial or syringe must not be used for more than one eye

Medicine interactions

  • Tell the eye doctor about other anti-vascular-growth-factor injections and blood thinners
  • Do not combine treatments inside the eye except within a specialist plan

Pregnancy and breastfeeding

  • It may harm an unborn baby; tell your doctor if pregnant and use effective contraception as directed
  • Discuss breastfeeding with the doctor before treatment

How to store it

  • The eye clinic stores it under the pack conditions; it is not stored at home

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.