What it is used for
- Treating advanced (metastatic) kidney cancer in selected patients
- Treating advanced melanoma, in some countries
How it is used
- It is given only in hospital as a drip into a vein by a team experienced in cancer treatment
- It is given in courses planned by your specialist
- Heart and lung function are checked before treatment, and blood pressure, weight, urine output and blood tests are closely watched during it
Possible side effects
- Fluid leaking from blood vessels, causing low blood pressure, swelling, weight gain and reduced kidney function
- Fever, chills and flu-like symptoms
- Nausea, vomiting and diarrhoea
- Confusion, marked drowsiness or mood changes
- Rash, itching and a higher risk of infection
Who should not use it
- Serious heart or lung disease, or abnormal heart or lung tests
- People who have had an organ transplant
- Allergy to aldesleukin or any of its ingredients
Before and while using it
- Fluid leak can be dangerous, which is why treatment is given under close monitoring
- It increases the risk of serious bacterial infection; tell the team about any fever or redness around a line
- Tell the team at once about any confusion or marked drowsiness
- It can cause immune problems of the thyroid or other organs that need follow-up
- Do not drive after treatment until your doctor says you can
Medicine interactions
- Steroids can reduce the effect of treatment and are used only if the doctor decides
- Blood pressure medicines can make low blood pressure worse
- Medicines that can harm the kidneys, liver or heart need caution
- Iodine contrast dyes can cause delayed reactions after treatment; tell the X-ray team
Pregnancy and breastfeeding
- It is not used in pregnancy; use effective contraception during treatment as your doctor advises
- Do not breastfeed during treatment
How to store it
- It is stored and prepared in the hospital pharmacy
Get medical help straight away if
- Your face, lips or tongue swell, or you find it hard to breathe.
- You get a severe rash, blistering or peeling skin.
- A side effect worries you or doesn’t go away: contact your doctor or pharmacist.
Questions about this medicine?
Talk to a doctor by video, or send your question by text.
Source: Standard international medicine references
This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.