PCSK9-inhibiting monoclonal antibody

Alirocumab (أليروكوماب)

Alirocumab is an injection under the skin that lowers LDL cholesterol by blocking a protein that keeps it high. It is used with diet and often other medicines, with cholesterol monitoring and injection training.

What it is used for

  • Treating familial or non-familial high cholesterol or mixed dyslipidaemia
  • Reducing cardiovascular risk in adults with established cardiovascular disease
  • Use with a statin or another medicine, or when a statin is not tolerated, as decided by a clinician

How it is used

  • Inject under the skin of the abdomen, thigh or upper arm after training and follow your clinician's schedule
  • Allow the pen or syringe to reach room temperature as directed by the leaflet without heating it
  • Inspect the solution and do not use it if discoloured, cloudy or containing particles
  • Rotate injection sites and avoid skin that is sore, infected or bruised
  • Do not change the regimen or stop other cholesterol medicines without consulting your clinician

Possible side effects

  • Pain, redness, itching or swelling at the injection site
  • Cold- or flu-like symptoms
  • Itching or skin rash
  • Rarely, a severe allergic reaction with swelling or breathing difficulty

Who should not use it

  • Allergy to alirocumab or any ingredient in the product

Before and while using it

  • Get urgent help for swelling of the face or throat, breathing difficulty or a severe rash
  • Continue diet and other lipid-lowering medicines as advised
  • Cholesterol testing is needed to assess response and select the appropriate regimen
  • Make sure you understand how to use the pen or syringe before self-injecting

Medicine interactions

  • No important medicine interactions are known, but tell your clinician about all cholesterol medicines and supplements
  • Do not mix it with another medicine in the same syringe

Pregnancy and breastfeeding

  • Tell your doctor if you are pregnant or planning pregnancy because information is limited
  • Discuss breastfeeding with your doctor because transfer into milk and effects on the baby are not well established

How to store it

  • Keep refrigerated in its carton to protect from light, and do not freeze or shake
  • Follow the leaflet if stored outside the refrigerator and keep pens and syringes away from children

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.