Antiemetic (dopamine antagonist)

Alizapride (أليزابريد)

Alizapride is an anti-sickness medicine related to metoclopramide. It is given as an injection in hospital or clinic to prevent or treat nausea and vomiting, for example with chemotherapy or after surgery.

What it is used for

  • Preventing and treating nausea and vomiting with chemotherapy or radiotherapy
  • Nausea and vomiting after surgery

How it is used

  • It is given as an injection into a vein or muscle by a nurse or doctor
  • Your doctor decides the dose and how long to use it

Possible side effects

  • Drowsiness or tiredness
  • Dizziness
  • Involuntary movements of the face, neck or eyes, especially in young people
  • Rarely, breast swelling or changes in periods

Who should not use it

  • Allergy to alizapride
  • Phaeochromocytoma (an adrenal gland tumour)
  • Blockage, bleeding or a tear in the gut
  • A history of long-lasting involuntary movements caused by medicines such as metoclopramide or antipsychotics

Before and while using it

  • Tell the staff at once about any involuntary movements or muscle stiffness
  • Tell your doctor if you have Parkinson's disease, epilepsy or kidney disease
  • It can cause drowsiness; do not drive after the injection until it wears off
  • Children and older people are more sensitive to its side effects

Medicine interactions

  • Levodopa and other Parkinson's medicines, as each reduces the other's effect
  • Alcohol and sedatives increase drowsiness
  • Antipsychotics and metoclopramide increase the risk of involuntary movements

Pregnancy and breastfeeding

  • Information is limited; it is used in pregnancy or breastfeeding only if your doctor decides it is needed

How to store it

  • Ampoules are stored away from light and handled by healthcare staff

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.