Plasma-derived protein (augmentation therapy)

Alpha-1 proteinase inhibitor (human) (مثبط ألفا واحد بروتيناز البشري)

This medicine replaces the alpha-1 antitrypsin protein in people with severe inherited deficiency who have developed emphysema, to slow lung damage. It is made from donated human plasma and given regularly as a drip into a vein.

What it is used for

  • Long-term replacement in adults with severe alpha-1 antitrypsin deficiency and emphysema, as a specialist decides
  • Slowing the loss of lung tissue in this condition

How it is used

  • It is given as a drip into a vein by a nurse, or at home by a trained person if your doctor decides
  • The powder is dissolved and given as the leaflet directs, at regular intervals set by your doctor
  • Stopping smoking is essential for benefit; keep using your inhalers and having vaccines as your doctor advises

Possible side effects

  • Headache or dizziness
  • Fever, chills or flu-like symptoms
  • Nausea
  • Rash or itching, and rarely a severe allergic reaction

Who should not use it

  • IgA deficiency with antibodies against IgA
  • Allergy to human plasma proteins or any ingredient of the product

Before and while using it

  • Stop the drip and get help at once for breathlessness, facial swelling or a widespread rash
  • Because it is made from human plasma there is a very small risk of passing on infection despite careful testing; your doctor may advise hepatitis vaccines
  • Tell your doctor if you have heart disease, as the fluid volume may need watching

Medicine interactions

  • No important drug interactions are known, but tell your doctor about all your medicines

Pregnancy and breastfeeding

  • Information is limited; your doctor decides about using it in pregnancy or breastfeeding

How to store it

  • Store it as the pack directs, do not freeze it, and keep it out of the reach of children

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.