Anti-anxiety medicine (benzodiazepine)

Alprazolam (ألبرازولام)

Alprazolam is a benzodiazepine that eases anxiety and panic attacks by calming brain activity. It is used for short periods because it can cause dependence, and it is a controlled medicine.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Short-term treatment of severe anxiety
  • Treating panic disorder

How it is used

  • Use it only as prescribed by your doctor; your doctor decides the dose and how long to take it
  • Tablets are swallowed with water; modified-release tablets are swallowed whole without chewing or breaking
  • Do not stop it suddenly after regular use; your doctor will reduce the dose gradually
  • Never give your medicine to anyone else

Possible side effects

  • Drowsiness, dizziness or tiredness
  • Poor concentration or forgetfulness
  • Poor balance and unsteadiness, especially in older people
  • Rarely, unexpected agitation or aggression

Who should not use it

  • Do not use it if you are allergic to the active ingredient or any other ingredient in the product
  • Severe breathing problems or sleep apnoea
  • Myasthenia gravis or severe liver disease
  • Taking ketoconazole or itraconazole

Before and while using it

  • It can cause dependence and addiction, especially with long use, high doses or a past history of addiction
  • Stopping suddenly can cause serious withdrawal symptoms, including fits
  • Taking it with opioid painkillers or alcohol can cause severe drowsiness and slowed breathing that can be life-threatening
  • Do not drive or use machines if you feel drowsy
  • Tell your doctor if you have depression or thoughts of self-harm, or lung or kidney disease

Medicine interactions

  • Opioid painkillers, alcohol, sleeping tablets and drowsy antihistamines: risk of severe drowsiness and slowed breathing
  • Some antifungals, antibiotics and HIV medicines raise its level in the blood
  • Some epilepsy medicines, rifampicin and St John's wort can reduce its effect
  • Tell your doctor or pharmacist about all the medicines, supplements and herbal products you take

Pregnancy and breastfeeding

  • It is avoided in pregnancy because it can cause withdrawal and floppiness in the newborn; tell your doctor if you are pregnant or planning a pregnancy
  • It passes into breast milk and can make the baby drowsy; it is not recommended while breastfeeding

How to store it

  • Store it safely at room temperature, out of the sight and reach of children, and do not keep tablets you no longer need.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.