Clot-dissolving medicine (injection)

Alteplase (ألتيبلاز)

Alteplase dissolves blood clots and is given into a vein in hospital. It is used in emergencies such as stroke caused by a clot, a large lung clot and heart attack.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Stroke caused by a clot, after a scan rules out bleeding in the brain
  • Sudden large clot in the lungs (massive pulmonary embolism)
  • Acute heart attack

How it is used

  • It is given by a doctor or nurse, usually in hospital.
  • It must be given as soon as possible after symptoms start; time is critical.
  • The medical team monitors you and your vital signs during treatment.

Before and while using it

  • It greatly increases bleeding risk, so the medical team watches you closely.
  • Tell the doctor right away about any recent bleeding, surgery or past brain bleed.
  • Tell the doctor about any blood thinners you take.
  • Tell the team immediately about any bleeding, severe headache or sudden weakness.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: National drug formulary 2024, page 188

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.