Iodinated contrast medium

Amidotrizoic acid (diatrizoate) (حمض الأميدوتريزويك)

Amidotrizoic acid (diatrizoate) is an iodine-containing contrast dye that makes parts of the body show up clearly on X-rays. The solution taken by mouth or as an enema outlines the gullet, stomach and bowel, and the injection outlines the urinary tract and vessels in some older tests, now mostly replaced by newer dyes. The X-ray team gives it.

What it is used for

  • X-rays of the gullet, stomach and bowel when barium is unsuitable, for example if a tear or leak is suspected
  • Outlining the bowel before a CT scan
  • Urinary tract and other X-ray tests by injection, now mostly replaced by newer dyes
  • Sometimes in hospital as an enema or by mouth to help treat certain types of bowel blockage, as a specialist decides

How it is used

  • The solution is drunk, sometimes diluted or given through a tube, before or during the test as the staff direct
  • The enema and the injection into a vein are given only by the X-ray team
  • Drink plenty of fluids after the test unless the staff tell you otherwise

Possible side effects

  • By mouth or rectum: diarrhoea, nausea and vomiting
  • By injection: a feeling of warmth, a metallic taste and nausea
  • Allergic reactions such as rash and itching, and rarely a severe reaction
  • Reduced kidney function after injection in people at risk
  • Dehydration in infants and older people with the solution taken by mouth

Who should not use it

  • A previous severe allergic reaction to iodine contrast dyes
  • An uncontrolled overactive thyroid
  • It must never be injected into the spinal canal

Before and while using it

  • Tell the staff about any previous reaction to contrast dyes, asthma or allergies
  • Tell the staff if you have kidney disease, or diabetes and take metformin
  • Breathing the solution into the lungs while swallowing can cause serious lung inflammation; tell the staff if you have trouble swallowing
  • Tell the staff if you have thyroid disease, as the iodine can affect it
  • A delayed rash can appear hours or days later; tell your doctor if it happens

Medicine interactions

  • Metformin may need a short pause around the injection in people with kidney problems, as the doctor decides
  • Beta-blockers can make an allergic reaction harder to treat
  • Interleukin-2 treatment increases the risk of delayed reactions
  • It can affect thyroid test results for several weeks; tell your doctor you have had a contrast test

Pregnancy and breastfeeding

  • Tell the staff if you are or might be pregnant, as the iodine can affect the baby's thyroid
  • Breastfeeding can usually continue after the test

How to store it

  • It is stored in hospital away from light

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.