Antipsychotic (second generation)

Amisulpride (أميسولبرايد)

Amisulpride is an antipsychotic medicine that acts on dopamine, a chemical messenger in the brain. It is mainly used to treat schizophrenia.

What it is used for

  • Treating schizophrenia, both acute episodes and long-term
  • In some countries, treating long-lasting mild low mood (dysthymia), as decided by a specialist

How it is used

  • Tablets are taken by mouth exactly as your doctor prescribed; your doctor decides the dose
  • Swallow them with water, preferably before meals
  • Keep taking it even if you feel better, and do not stop without asking your doctor

Possible side effects

  • A raised milk hormone (prolactin), which can cause breast swelling, milk discharge, period changes or sexual problems
  • Restlessness, tremor or muscle stiffness
  • Sleepiness or difficulty sleeping
  • Weight gain

Who should not use it

  • Do not take it if you are allergic to amisulpride or any ingredient in the tablets
  • Tumours that depend on prolactin, such as some pituitary or breast tumours
  • Phaeochromocytoma (a tumour of the adrenal gland)
  • Children who have not reached puberty

Before and while using it

  • It can affect heart rhythm; tell your doctor if you have heart disease or low potassium, as you may need a heart tracing (ECG)
  • Tell your doctor if you have kidney disease, epilepsy or have had blood clots
  • In older people with dementia, antipsychotics increase the risk of stroke and death
  • Get urgent help for high fever with stiff muscles and confusion, or for palpitations or fainting
  • It can cause sleepiness; do not drive until you know how it affects you, and avoid alcohol

Medicine interactions

  • Other medicines that affect heart rhythm, such as some heart rhythm medicines, some antibiotics, and other antipsychotics and antidepressants
  • Levodopa and other Parkinson's medicines, as each reduces the effect of the other
  • Alcohol and sedating medicines add to the sleepiness

Pregnancy and breastfeeding

  • Tell your doctor if you are pregnant or planning a pregnancy; use late in pregnancy can cause temporary symptoms in the newborn, and do not stop it without asking your doctor
  • It is not recommended while breastfeeding unless your doctor advises it

How to store it

  • Store at room temperature away from heat and moisture, out of the sight and reach of children.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.