What it is used for
- Advanced non-small cell lung cancer with EGFR exon 20 insertion mutations, alone or with chemotherapy
- Advanced lung cancer with other common mutations in this gene, with lazertinib or with chemotherapy, as the oncologist decides
How it is used
- It is given only in hospital by the cancer team as a drip into a vein or an injection under the skin
- The first dose may be split over two days, with medicines beforehand to prevent infusion reactions
- When combined with lazertinib, your doctor may prescribe a blood thinner to prevent clots in the first months
- Attend regular blood tests and check-ups
Possible side effects
- Infusion or injection reactions such as chills, breathlessness and nausea
- An acne-like rash and dry, itchy skin
- Infection around the nails
- Swelling of the feet and low albumin
- Mouth sores, tiredness or constipation
Who should not use it
- Allergy to amivantamab or any of its ingredients
Before and while using it
- A new cough, breathlessness or fever may mean lung inflammation and needs urgent contact with the team
- Protect your skin from the sun and use moisturisers as advised, and report a severe rash
- Report any change in vision or eye pain
- Swelling of one leg, chest pain or sudden breathlessness can mean a clot and needs emergency help
Medicine interactions
- Combining it with lazertinib increases the risk of clots
- Tell the cancer team about all your medicines and herbal products before treatment
Pregnancy and breastfeeding
- It may harm an unborn baby; use effective contraception during treatment and for a period afterwards set by your doctor
- Do not breastfeed during treatment and for a period afterwards
How to store it
- It is kept in the fridge and prepared in hospital
Get medical help straight away if
- Your face, lips or tongue swell, or you find it hard to breathe.
- You get a severe rash, blistering or peeling skin.
- A side effect worries you or doesn’t go away: contact your doctor or pharmacist.
Questions about this medicine?
Talk to a doctor by video, or send your question by text.
Source: Standard international medicine references
This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.