Slow-acting symptomatic osteoarthritis treatment

Avocado–soybean unsaponifiables (مستخلصات الأفوكادو والصويا غير المتصبنة)

Avocado–soybean unsaponifiables are a defined mixture of oil fractions that do not form soap. In some countries they are used as a slow-acting treatment for pain and impaired movement in knee osteoarthritis, but benefit is limited, evidence varies between preparations and they do not rebuild cartilage.

What it is used for

  • Slow symptomatic relief of pain from knee osteoarthritis in adults
  • Reducing movement difficulty from knee osteoarthritis within a plan including activity, weight management and physiotherapy

How it is used

  • Take the capsule or tablet as directed by the leaflet, doctor or pharmacist and with food if the pack advises
  • Swallow the solid form whole with water and do not chew it if the leaflet prohibits this
  • Do not expect rapid relief or replace a prescribed pain reliever or physiotherapy with it
  • Check the amount and ratio of both extracts because different supplements are not equivalent to the studied preparation
  • Review other ingredients in combination joint products before using them together

Possible side effects

  • Diarrhoea or indigestion
  • Nausea or abdominal pain
  • Taste change or belching
  • Rash, itching or hives
  • Rarely, liver disturbance or jaundice

Who should not use it

  • Allergy to avocado, soya or any ingredient
  • A child or adolescent because efficacy and safety are not established
  • Severe liver disease without medical review

Before and while using it

  • Jaundice, dark urine or generalised itching can indicate liver injury and requires stopping and assessment
  • Rash, swelling or breathing difficulty can indicate avocado or soya allergy
  • Sudden joint pain with swelling, redness or fever needs assessment and should not be assumed to be osteoarthritis
  • Benefit can be delayed; do not continue indefinitely without review if there is no improvement
  • The product does not stop joint damage or replace activity, physiotherapy and weight management
  • Quality and composition of unlicensed supplements may differ from the studied medicinal preparation

Medicine interactions

  • No important interaction is established, but tell the doctor and pharmacist about every medicine and supplement
  • Review accompanying painkillers and anti-inflammatory medicines to avoid duplication or stomach and kidney harm
  • Combination products containing glucosamine or chondroitin have additional warnings and interactions

Pregnancy and breastfeeding

  • It is not recommended during pregnancy or breastfeeding because safety data are inadequate; ask the doctor about an alternative

How to store it

  • Store as directed, protected from moisture and heat and away from children

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.