Low-molecular-weight heparin anticoagulant

Bemiparin sodium (بيميبارين صوديوم)

Bemiparin is a low-molecular-weight heparin anticoagulant that reduces the formation or recurrence of venous blood clots. It is injected under the skin and requires prescription monitoring because bleeding and low platelets can be serious.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Prevention of venous blood clots after selected operations
  • Prevention of blood clots in non-surgical patients at increased risk
  • Treatment of deep-vein thrombosis and prevention of recurrence according to the local product
  • Prevention of clotting in the dialysis circuit for selected products and settings

How it is used

  • Use it only as prescribed and do not change the dose or treatment length yourself
  • It is injected into tissue under the skin of the abdomen; a professional teaches pre-filled syringe use if treatment is at home
  • Rotate injection sites and do not rub afterwards to reduce bruising
  • Do not inject into muscle or expel the air bubble unless the leaflet instructs you; place the used syringe in a sharps container
  • During dialysis, a professional gives the appropriate presentation into the blood circuit with monitoring

Possible side effects

  • Bruising, pain or a small collection of blood at the injection site
  • Nose or gum bleeding or easy bruising
  • Low platelet count
  • Raised potassium or liver enzymes
  • Severe bleeding or severe allergy in rare cases

Who should not use it

  • Active major bleeding or a condition with a high risk of uncontrolled bleeding
  • Current or previous immune heparin-induced thrombocytopenia
  • Allergy to bemiparin, heparin or product ingredients
  • Acute bacterial endocarditis, or recent brain, eye or ear injury or surgery with bleeding risk

Before and while using it

  • Seek urgent help for bleeding that does not stop, vomiting blood, black stools, a sudden severe headache or weakness
  • Platelet count, kidney function and potassium require monitoring according to risk factors
  • Tell the clinician before surgery, dental treatment or a spinal procedure
  • Spinal anaesthesia or an epidural catheter can cause a blood collection that compresses nerves; immediately report back pain, leg weakness or loss of bladder control
  • Kidney or liver disease, ulcer disease and uncontrolled high blood pressure increase bleeding risk
  • Do not exchange it unit-for-unit with another heparin because products are not equivalent

Medicine interactions

  • Other anticoagulants, antiplatelet medicines and clot-dissolving drugs increase bleeding risk
  • Aspirin and NSAIDs can increase bleeding unless the doctor decides they are necessary
  • Corticosteroids and other medicines affecting clotting require review
  • Medicines and supplements that raise potassium can worsen hyperkalaemia in susceptible people

Pregnancy and breastfeeding

  • Use during pregnancy only after the doctor assesses clotting and bleeding risks and selects an appropriate product
  • Breastfeeding data are limited; the doctor decides treatment after weighing benefits and risks

How to store it

  • Store in the original pack as the leaflet directs, away from heat and out of children's reach; do not freeze

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.