Antipsychotic (second generation)

Brexpiprazole (بريكسبيبرازول)

Brexpiprazole is an antipsychotic that balances brain chemicals such as dopamine and serotonin. It is used for schizophrenia and, in some countries, added to an antidepressant for major depression.

What it is used for

  • Treating schizophrenia in adults
  • Added to an antidepressant for major depression when the antidepressant alone is not enough, as your doctor decides

How it is used

  • Use it only as prescribed by your doctor; your doctor decides the dose and increases it gradually
  • Tablets are swallowed with water, with or without food, at about the same time each day
  • Do not stop it or change the dose without asking your doctor, even if you feel better

Possible side effects

  • Weight gain
  • A feeling of inner restlessness and difficulty keeping still
  • Sleepiness, headache or dizziness
  • Tremor or muscle stiffness

Who should not use it

  • Do not use it if you are allergic to the active ingredient or any other ingredient in the product

Before and while using it

  • It raises the risk of death and stroke in older people with dementia; it is used for them only when a specialist decides
  • Tell your doctor straight away about any thoughts of self-harm or sudden mood changes, especially in young people at the start of treatment
  • It can increase weight, blood sugar and blood fats; your doctor will check these during treatment
  • It can cause strong urges that are hard to resist, such as gambling, eating or shopping; tell your doctor if you or your family notice this
  • Get medical help straight away for high fever with severe muscle stiffness, confusion or sweating, or for uncontrollable movements of the face or tongue
  • It can cause dizziness on standing and drowsiness; get up slowly and do not drive until you know how it affects you

Medicine interactions

  • Fluoxetine, paroxetine, clarithromycin and some antifungals can raise its level in the blood
  • Rifampicin, carbamazepine and St John's wort can make it less effective
  • Alcohol, sedatives and sleeping tablets: drowsiness may increase
  • Tell your doctor or pharmacist about all the medicines, supplements and herbal products you take

Pregnancy and breastfeeding

  • Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding; use late in pregnancy can cause temporary movement or breathing symptoms in the newborn, and do not stop the medicine yourself

How to store it

  • Store at room temperature away from heat and moisture, out of the sight and reach of children.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.