Long-acting local anaesthetic

Bupivacaine (بوبيفاكايين)

Bupivacaine is a local anaesthetic that blocks pain in part of the body for several hours. It is injected by an anaesthetist or surgeon for spinal or epidural anaesthesia, nerve blocks or into the surgical area.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Spinal anaesthesia for operations, including caesarean section
  • Epidural anaesthesia for labour pain and pain after surgery
  • Nerve blocks and injection into the surgical area to relieve pain

How it is used

  • It is given only by injection by an anaesthetist or surgeon in hospital or clinic.
  • The doctor decides the dose and where to inject, and the medical team monitors you during and after the injection.
  • After the injection the numb area may stay without feeling for hours; protect it from injury and burns until feeling returns.

Possible side effects

  • Low blood pressure and slow heart rate, especially with spinal anaesthesia
  • Nausea or vomiting
  • Headache after spinal anaesthesia
  • Temporary difficulty passing urine

Who should not use it

  • It is not used if you are allergic to local anaesthetics of the same type (such as lidocaine)
  • It is not given into a vein or for intravenous regional anaesthesia (Bier's block)
  • Spinal and epidural injections are not given with severe clotting problems or infection at the injection site

Before and while using it

  • Tell the doctor if you take blood thinners or have a bleeding disorder.
  • Tell the doctor if you have heart disease, liver disease or epilepsy.
  • Tell the medical team straight away if you feel numbness around the mouth, ringing in the ears, dizziness or a metallic taste; these can be signs of toxicity.
  • Tell the doctor if you develop severe back pain or leg weakness that does not improve after a spinal or epidural.

Medicine interactions

  • Heart rhythm medicines (such as amiodarone) and other local anaesthetics increase the risk of toxicity.
  • Anticoagulants and antiplatelet medicines increase the risk of bleeding around the spinal cord with spinal or epidural injections.

Pregnancy and breastfeeding

  • It is widely used for labour and caesarean section at the anaesthetist's decision, and breastfeeding can usually continue afterwards.

How to store it

  • Hospital or clinic staff store and prepare this medicine.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.