Gonadotrophin-releasing-hormone antagonist

Cetrorelix (سيتروريليكس)

Cetrorelix temporarily blocks a pituitary hormone signal to prevent premature ovulation during ovarian stimulation for fertility treatment. It is used only within a fertility-centre plan with hormone and ultrasound monitoring.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Preventing premature ovulation during controlled ovarian stimulation
  • Supporting an assisted-reproduction cycle until egg collection at the time set by the centre

How it is used

  • After fertility-centre training, gently mix the powder with its supplied solvent and use it promptly as directed
  • Inject it under the lower-abdominal skin at the time set by the fertility team and rotate the site
  • Do not shake the solution or use it if cloudy or particulate
  • Contact the centre after a missed injection and never double it or change timing yourself
  • Attend every scheduled hormone test, ultrasound scan and clinical review

Possible side effects

  • Redness, itching or swelling at the injection site
  • Headache or nausea
  • Abdominal pain or swelling from the ovarian-stimulation programme
  • Rare severe allergy

Who should not use it

  • Allergy to cetrorelix, related hormone medicines or any ingredient
  • Pregnancy or breastfeeding
  • Severe kidney or liver disease as defined by the label

Before and while using it

  • Breathing difficulty, facial swelling or a widespread rash after injection needs emergency care
  • Severe abdominal pain, rapid swelling, vomiting or breathlessness can indicate ovarian hyperstimulation and needs urgent contact with the centre
  • Ovarian torsion, a clot or ectopic pregnancy are fertility-programme risks, and acute symptoms need assessment
  • It must not be used without monitoring because incorrect timing can allow premature ovulation and affect the cycle
  • Tell the centre about any previous severe allergy to fertility medicines

Medicine interactions

  • Other fertility medicines form part of a coordinated protocol and must not be started or stopped yourself
  • Tell the centre about every medicine and herb because interaction studies are limited

Pregnancy and breastfeeding

  • It is contraindicated in pregnancy; the centre confirms the treatment stage and stops it before pregnancy progresses
  • It is not used during breastfeeding because safety information is inadequate

How to store it

  • Keep the pack refrigerated and protected from light, never freeze it, and use prepared solution as the leaflet directs

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.