Progestogen used in a combined contraceptive pill

Chlormadinone acetate (كلورمادينون)

Chlormadinone is a man-made progestogen used with ethinylestradiol in a combined contraceptive pill. It stops ovulation and thickens cervical mucus, and it also has a mild anti-male-hormone effect.

What it is used for

  • Preventing pregnancy
  • Your doctor may choose it for women who also have mild acne, because of its anti-male-hormone effect

How it is used

  • Swallow the pills in the order shown on the pack, at about the same time each day
  • Follow the leaflet exactly if you miss a pill; you may need extra protection such as condoms
  • Vomiting or severe diarrhoea can reduce protection; follow the leaflet

Possible side effects

  • Bleeding or spotting between periods, especially in the first months
  • Breast tenderness, headache or nausea
  • Changes in mood or sex drive

Who should not use it

  • A past or current blood clot, or a high risk of clots
  • Migraine with aura, such as visual disturbances
  • Breast cancer or severe liver disease
  • Smoking if you are over 35

Before and while using it

  • Get help straight away for leg pain and swelling, sudden chest pain, breathlessness or sudden weakness
  • Your blood pressure needs to be checked regularly
  • It does not protect against sexually transmitted infections
  • Tell your doctor before major surgery or a long period of immobility

Medicine interactions

  • Rifampicin, some epilepsy medicines and St John's wort make the pill less effective
  • Some hepatitis C medicines must not be used with it
  • Tell your doctor or pharmacist about all the medicines, supplements and herbal products you take

Pregnancy and breastfeeding

  • It is not used in pregnancy; stop it and see your doctor if you become pregnant
  • It is not recommended while breastfeeding because it can reduce milk supply

How to store it

  • Store it at room temperature in the original pack, away from moisture and out of the sight and reach of children

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.