Antimuscarinic for overactive bladder

Darifenacin (داريفيناسين)

Darifenacin relaxes the bladder muscle and reduces unwanted contractions. It is prescribed for adults with overactive bladder to reduce urgency, frequent urination and urine leakage.

What it is used for

  • Reducing sudden urinary urgency
  • Reducing frequent urination
  • Treating urgency incontinence caused by overactive bladder

How it is used

  • Take the prolonged-release tablet as prescribed at a regular time
  • Swallow the tablet whole with water; do not crush, chew or split it
  • It may be taken with or without food, and avoid grapefruit if your clinician advises it
  • Do not stop or change it without speaking to your clinician even if improvement takes time

Possible side effects

  • Dry mouth
  • Constipation, abdominal pain or indigestion
  • Headache or dizziness
  • Dry eyes or blurred vision
  • Difficulty passing urine or urinary retention

Who should not use it

  • Urinary retention or severe gastric retention
  • Uncontrolled narrow-angle glaucoma
  • Myasthenia gravis, severe ulcerative colitis or toxic megacolon
  • Severe liver impairment or use of a strong inhibitor of the liver enzyme that clears it

Before and while using it

  • Tell your clinician about difficulty emptying the bladder, urinary obstruction or severe constipation before treatment
  • Seek help if you cannot pass urine or develop severe abdominal pain and swelling
  • It can reduce sweating and increase the risk of heat illness in hot weather
  • It can cause blurred vision, dizziness or sleepiness; do not drive if affected
  • Seek urgent help for swelling of the face or tongue or difficulty breathing

Medicine interactions

  • Some antibiotics, antifungals and antiviral medicines can greatly raise its level
  • Other anticholinergic medicines can worsen dry mouth, constipation and urinary retention
  • Some medicines for depression, psychosis or heart conditions may need dose review or monitoring
  • Grapefruit can raise the medicine level; follow your clinician's advice

Pregnancy and breastfeeding

  • Tell your clinician if you are pregnant or planning pregnancy; it is generally avoided because information is limited
  • Use during breastfeeding requires caution after weighing treatment benefit and possible risk

How to store it

  • Keep in the original pack, away from moisture and children's reach

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.