Peripheral kappa-opioid receptor agonist for itch

Difelikefalin (ديفيليكيفالين)

Difelikefalin is an injection given after a haemodialysis session to relieve moderate to severe itching linked to chronic kidney disease. It works mainly on nerve receptors outside the brain.

What it is used for

  • Treating moderate to severe itching from chronic kidney disease in adults on haemodialysis

How it is used

  • The dialysis team gives it into the dialysis line at the end of a session
  • The doctor sets the dose by dry weight; it is not given at home

Possible side effects

  • Dizziness or drowsiness
  • Diarrhoea or nausea
  • Headache
  • Tingling or altered sensation

Who should not use it

  • Do not use it if you are allergic to difelikefalin or any ingredient in the product

Before and while using it

  • It can cause dizziness or drowsiness; do not drive if affected
  • Tell your doctor if you have severe liver disease
  • Older people are more prone to dizziness and falls

Medicine interactions

  • Sedatives, opioid painkillers, alcohol and sleeping tablets can add to drowsiness and dizziness
  • Tell your doctor or pharmacist about all medicines, supplements and herbal products you take

Pregnancy and breastfeeding

  • Do not use it in pregnancy or breastfeeding unless your doctor advises it, as information is limited

How to store it

  • The hospital or pharmacy stores it as the leaflet directs; it is not kept at home.

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.