Centrally acting sexual-desire modulator

Flibanserin (فليبانسرين)

Flibanserin is a prescription medicine for acquired, generalised low sexual desire that causes marked distress in selected women. It does not enhance sexual performance, and medical, mental-health, medicine-related and relationship causes must be excluded first.

This medicine is used under close medical supervision, usually by a specialist. Never start, stop or change it without your doctor.

What it is used for

  • Treating acquired, generalised hypoactive sexual desire disorder in women who meet the diagnostic criteria
  • Improving desire and reducing related distress when a clinician decides the expected benefit outweighs the risks

How it is used

  • Take it only as prescribed and at bedtime to reduce sleepiness, low blood pressure and fainting risk
  • Swallow the tablet with water and do not take a daytime dose to replace one you missed
  • Follow the clinician's instructions exactly about separating alcohol and the medicine; you may be told to skip a dose depending on alcohol amount and timing
  • Avoid driving or alertness-dependent work until the leaflet's stated interval has passed and you know its effect on you
  • The clinician will assess response and stop it if there is no clear benefit; do not stop or restart it yourself

Possible side effects

  • Dizziness, sleepiness or tiredness
  • Nausea or dry mouth
  • Insomnia or anxiety
  • Low blood pressure, near-fainting or fainting
  • Rarely, severe allergy with swelling of the face or mouth

Who should not use it

  • Any degree of liver impairment
  • Use with a moderate or strong inhibitor of the liver enzyme that clears it
  • Allergy to flibanserin or any ingredient

Before and while using it

  • Alcohol close to the dose can cause severe low blood pressure and fainting; follow individual instructions exactly
  • Lie down and get help if you feel faint, and seek urgent care if symptoms do not settle or you lose consciousness
  • Tell the clinician and pharmacist before any new medicine or herb because some interactions raise its level dangerously
  • Sleepiness increases with sedatives, sleeping medicines, opioid painkillers and some antihistamines
  • It is not for low desire caused by an untreated illness, medicine, mental-health or relationship problem, or for enhancing performance

Medicine interactions

  • Antifungals, some antibiotics, HIV medicines and grapefruit juice can raise its level and cause low blood pressure; many are contraindicated
  • Rifampicin, carbamazepine, phenytoin and St John's wort can reduce its effect and are not recommended with it
  • Alcohol, sedatives, sleeping medicines and opioids increase low blood pressure and nervous-system depression
  • It can raise digoxin and some other narrow-margin medicines, which may need monitoring

Pregnancy and breastfeeding

  • Tell the doctor if you are pregnant or planning pregnancy; human information is insufficient to define the risk
  • Breastfeeding is not recommended during treatment because it may enter milk and could cause serious effects in the infant

How to store it

  • Keep tablets in their pack at room temperature, away from moisture and children's reach

Get medical help straight away if

  • Your face, lips or tongue swell, or you find it hard to breathe.
  • You get a severe rash, blistering or peeling skin.
  • A side effect worries you or doesn’t go away: contact your doctor or pharmacist.

Questions about this medicine?

Talk to a doctor by video, or send your question by text.

Source: Standard international medicine references

This guide is general information and doesn’t replace advice from your doctor or pharmacist. Don’t start, stop or change a medicine without asking them, and always read the leaflet in the pack.